Cooking with stem ginger8/18/2023 Some research suggests ginger may have anti-diabetic properties. May lower blood sugar and improve heart disease risk factors Some studies suggest ginger can help reduce symptoms of osteoarthritis, especially osteoarthritis of the knee. However, many discontinued treatment as they did not like the taste of ginger or because it upset their stomach. ![]() However, other research has not found evidence of the same effects. One review concluded that ginger may help reduce pain and disability.The participants took 0.5–1 gram of ginger per day for 3–12 weeks, depending on the study. Osteoarthritis (OA) involves degeneration of the joints, leading to symptoms such as joint pain and stiffness. These include body weight and the waist-hip ratio. SUMMARYĪccording to studies in animals and humans, ginger may help improve weight-related measurements. Get some tips on using ginger for weight loss. Ginger’s ability to influence weight loss may be due to certain mechanisms, such as its potential to reduce inflammation. One 2019 review concluded that ginger supplementation significantly reduced body weight, the waist-hip ratio, and the hip ratio in people with overweight or obesity. Ginger may play a role in weight loss, according to studies in humans and animals. Taking ginger every day may help prevent morning sickness and other types of nausea. Learn more about using ginger for nausea. It may also be unsuitable for those with clotting disorders. Ginger may not be suitable during pregnancy for people who are close to labor and those with a history of pregnancy loss or vaginal bleeding. While generally safe, it’s best to talk with a doctor before taking large amounts if you’re pregnant. Ginger may help relieve nausea and vomiting for people undergoing certain types of surgery, and it may also help reduce chemotherapy-related nausea. Ginger may be effective against nausea, including pregnancy-related nausea, commonly known as morning sickness. Can treat morning sickness and other forms of nausea Ginger is high in gingerol, a substance with potent anti-inflammatory and antioxidant properties. What is ginger oil and does it have health benefits? SUMMARY For instance, it may help reduce oxidative stress, which results from having too many free radicals in the body. Gingerol has powerful anti-inflammatory and antioxidant effects, according to research. ![]() It’s responsible for many of ginger’s medicinal properties. Gingerol is the main bioactive compound in ginger. The unique fragrance and flavor of ginger come from its natural oils, the most important of which is gingerol. It’s been used to aid digestion, reduce nausea, and help fight the flu and common cold, to name a few of its purposes. Ginger has a long history of use in various forms of traditional and alternative medicine. Contains gingerol, which has potent medicinal properties ![]() Share on Pinterest Lucy Lambriex/Getty Images 1.
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Jihosoft iphone data recovery locked8/18/2023 ![]() Recover from iTunes or iCloud Backup: For lost, broken or smashed iOS devices, this iPhone/iPad/iPod Data Recovery software allows you to retrieve files by extracting backup data in iTunes/iCloud without connecting your iOS device to computer.ĭata Recovery Software for All iPhone, iPad & iPod Touch Models.Recover from iPhone, iPad & iPod Touch: Whether you lost iPhone, iPad, or iPod files due to accidental deletion, system crash, or restore to factory settings, just connect your iOS device to computer, the iOS Data Recovery program will directly scan the device and recover lost data.Recover Data from iOS Devices Directly and iTunes/iCloud Backup ![]() This utility allows you to free preview lost data before recovery and selectively recover what you want. You can recover lost data from iOS devices directly or retrieve precious data from iTunes/iCloud Backup. Jihosoft Mobile Recovery for iOS provides you with 2 quick and simple ways to get them all back. ![]() Easy to use, get back lost data from iOS device with only 3 simple stepsĪccidentally deleted contacts, messages, photos, videos, WhatsApp, Viber or other important stuff on your iPhone, iPad, iPod Touch? Don’t worry.Totally compatible with all iOS versions, including the latest iOS 10.Recover deleted contacts, messages, pictures, notes, and more than 16 types.Retrieve lost files by extracting iTunes/iCloud backup if iOS devices got lost.Recover deleted/lost data from iPhone, iPad & iPod Touch directly. Kudos pinot noir8/18/2023 The climate, unique soils and the innovation of so many talented individuals, have come together to deliver an accolade the region wholeheartedly deserves. This new achievement gives Hawke's Bay a unique positioning in New Zealand and the world. "We have long known that Hawke's Bay, as New Zealand's Food and Wine Country, stood out for its winemaking. It is recognition that Hawke's Bay wines are among the world's best, and that our nation's wine growing industry, while still young, offers quality to rival the world's oldest," he continued. "Hawke's Bay's inclusion as one of just 12 Great Wine Capitals of the world is of regional and national significance. "Cyclone Gabrielle may have dealt us a blow, but this recognition shows that Hawke's Bay is still the top-quality wine destination it always was," said Hawke's Bay Tourism CEO Hamish Saxton, announcing the Great Wine Capital status. The worldwide kudos comes as Hawke's Bay continues to recover from Cyclone Gabrielle in February 2023, offering a much-needed piece of good news in a tough year. Visitors to the area can enjoy everything from bike tours between cellar doors and long vineyard lunches to picnics and picking parties, plus ample opportunities to pair a glass or bottle with something to eat. The North Island region's variety of tourism experiences also boosted its fortunes, as well as its popularity with both NZ and international travellers. ![]() Hawke's Bay has been recognised for its 200-plus vineyards, 125 wine producers and more than 30 cellar doors - and growing more than 40,000 tonnes of grapes in 2022 alone. Joining the ranks isn't easy, involving a tough selection process that examines the region's winegrowing industry and vino tourism alongside its history, educational opportunities and more. All of the above places have received Great Wine Capital status already, and so have Cape Town's Cape Winelands in South Africa, Mainz and the Rheinhessen wine region in Germany, Valparaíso Casablanca Valley in Chile and fair Verona in Italy. ![]() The global program celebrates spots responsible for top-notch drops, and it's a prestigious list. ![]() So should New Zealand's Hawke's Bay, your next must-visit destination for a vino getaway, with the Aotearoa locale just earning a massive honour: being named the 12th Great Wine Capital of the world. Lausanne in Switzerland, Portugal's Porto, Mendoza in Argentina and Adelaide right here in Australia might as well. Think exceptional wine regions and Bordeaux, the Napa Valley and Bilbao likely come to mind. Im pro life change my mind hat8/18/2023 He questioned why anti-abortion advocates cared so much in the first place. ![]() Oz, who would be the first Muslim elected to the Senate, considers himself “ 100% pro-life” and has incorporated faith-based initiatives into his programming. Kay Ivey had signed earlier that month-a so-called “heartbeat” bill which outlawed abortion in almost every instance starting six weeks after conception-Oz denounced the idea as dangerous, unfair to women, and premised on misleading information. He then did not reply to a text message asking about his remarks in the abortion discussion.īut asked in 2019 about prohibitive laws like the near-total ban Alabama Republican Gov. Oz for comment, he picked up his phone and immediately ended the call. There are these moral issues that almost on purpose are inflamed.”Īnd yet, despite his full-throated support for abortion access in 2019, Oz said last week during an interview on WGAL in Lancaster that he was “OK with the Supreme Court making the right decision” on Roe, “based on what they think the Constitution says.”Įarlier that day, the high court heard arguments regarding a challenge to Mississippi’s prohibitive abortion law, with conservative justices signaling they were prepared to scrap Roe entirely.īut in the discussion with the Breakfast Club-hosted by rapper and political pundit “Charlamagne tha God”-Oz devoted several minutes to explaining why the resurgent anti-abortion movement concerned him as a physician, and why Roe was valuable and should not be overturned. To start picking fights on this-I always wonder about it,” he said. “There’s so much we gotta do already to take care of each other. Oz also questioned why restricting abortion access was so important to some people. “Just being logical about it,” he said, “if you think that the moment of conception you’ve got a life, then why would you even wait six weeks? Right, then an in vitro fertilized egg is still a life.” He would not want to “interfere with everyone else’s stuff,” he said, “because it’s hard enough to get into life as it is.” But he took a common pro-choice position in 2019 that his belief should not be forced onto others. Oz conceded that abortion “is a hard issue for everybody,” and he said that, on “a personal level,” he disliked abortion and would not want anyone in his family to have one. And I mean really traumatic events that happened when they were younger, before Roe v. “Because I went to medical school in Philadelphia, and I saw women who had coat-hanger events. ![]() “It’s, as a doctor-just putting my doctor hat on-it’s a big-time concern,” Oz said in the 2019 interview, which aired on the Breakfast Club radio show. Not only was Oz supportive of abortion rights, he seemed puzzled that people would spend time fighting abortion rights-going so far as to say that, as a physician, he was “really worried” about the anti-abortion movement and that eliminating Roe would have negative effects on women’s health. ![]() Wade.īut only two years earlier, Oz characterized efforts to overturn Roe as a misleading and possibly conspiratorial crusade. When the Supreme Court heard arguments last week for a case that could upend abortion rights nationwide, Mehmet Oz-the TV doctor and accused “quack” turned Republican candidate for Senate in Pennsylvania-suggested he was at peace that the Supreme Court could overturn Roe v. Torchlight 2 console command item sets8/18/2023 ![]() Now start the game and as soon as you are in game, playing with your character, you can open the console on the bottom by pressing the following keys simultaneously:Ĭlose the console again by clicking the red X in the upper right corner or you can press ESC. Note: By using some of these commands you character will be marked as cheater! Just change this line to "Console: 1" and save the txt file. Torchlight 2 Embermage Builds This guide will give you 4 different builds for the class, each at level 100, 145. Then open the settings.txt and look for the line containing "Console: 0". For more help on Torchlight 2, read our Outlander, Berserker and Engineer Builds. (but be aware, that you have to display hidden folders/files to be able to see the AppData folder) Therefore you have to find the "settings.txt" file depending on your operating system.Ĭ:\Documents and Settings\\AppData\Roaming\Runic Games\Torchlight Go wild with the full list of Torchlight 2 Developer Console Commands below. There’s God Mode, cheats to set your level, cheats to set your pet’s level, and a cheat that will spawn every item in the game. (to get specific piece follow above examples) Boots - Lists all the boots in the game. Many of these commands are untested, so try them at your own risk. You can remove that by stepping down the AA a bit, using the following command on the in-game console: r.postprocessaaquality 2 in the console. Not all commands will mark your game as modified. Official Website - Torchlight II Torchlight Release year: 2009 Developer: Runic Games Database features: Date 2938 Items Console name (cheats) Windows-application Torchlight 2 Release year: 2012 Developer: Runic Games Database features: Date 6050 Items Console name. You can acquire set items like any other item: from killing monsters, opening chests, breaking open objects, gambling, or completing quests. WARNING When playing online, modified versions of Torchlight 2 will be marked with a suspicious player flag. Set items are unique items that have bonuses that come from wearing items as a group. Disablepet - disables/enables players pet. This is a list of console cheats that you can enable in Torchlight 2. First of all you have to activate the console. While the dev console makes testing modifications easier, it’s also a great resource just to screw around with and have fun. Money Enter amount here - Spawn Amount of money. Barney harris nationality8/18/2023 ![]() I’m gay as well, I don’t go through life feeling like a victim. The vomitting emoji was definitely transphobic, I'll give you that. They aren't all bigoted, just morons with a bad sense of humor. Any example they used to mock Rafe would offend you, because it inherently would demean someone: most likely fat women or trans cross dressers, as those two in particular completely subvert the character.Īnd yes, I understand that society as a whole is at fault for making those two groups out to be a subversion of that, but it doesn't change the fact that is how many, many people see it. Their 'humor' is a reflection of being afraid that Rafe is going to subvert those traits by doing a trans cross dresser, even if it's a pretty lame attempt at humor. Cause let's face it, DQSH while an overall positive concept, is filled to the brim with a lot of horrendously ugly people (trans or not) and Lanfear is suppose to be oozing sexuality and feminine appeal. You just kinda seem overly sensitive towards this kind of humor. The real problematic ones are the ones blatantly against any lesbian relationships, or the folks offended that black people exist. It's still Rent cause we call it that, right?Įh.I've seen most of the threads you've linked and those don't even seem problematic in the slightest compared to other shit I've seen on this subreddit and others. Let's just make it about a bunch of Asian male roommates dealing with racist QAnon assholes with a subtheme of one of them getting AIDs from falling on a needle in the street. What if they recast the cast of Rent as all straight Asian men? How would you feel about that? Oh, and because they are straight and Asian let's remove the themes about gentrification, addiction, and the shame of sexually transmitted diseases. You don't change existing ones for the feelings of a small minority, and if you do it does not happen to major characters. If folks want to have a more inclusive cast, they can create new IPs to do so. That doesn't mean I'm okay with them butchering an existing character to promote an agenda, and yes, much of what Rafe is doing is an agenda. I love trans people, one of my closest friends is trans. You're right that a lot of people in this sub are being toxic towards LGBTQ and other minorities (not that I think u/-orb is), but they are also correct that forcing existing and popular characters to fundamentally change (in a way that will impact how their character is written) is also toxic. So my idea would be he and a group of male deathwatch guards would go to the black tower to see if they could learn the basics of channeling and he would be one of the ones that could learn and he would focus on healing. ![]() My idea would be that maybe Furyk Karede (the captain of the deathwatch) could become a male channeler because in almost his point of view he always touches that maybe the OP is not so bad and healing could maybe have saved his son. Like Lan impaling himself in the fight Demandred, and so on. Now, this is my fanfic because I grasping at straws, though all of WOT every time we see a point being brought up every now and then in the end it pays off in the end. And now knowing this Toun would start to create a personal guard of channelers inside the deathwatch, and slowly create a path where all damanes would be under her foot but free of the collars. My idea about where the story could go is that during the last Battle Hawkwing would tell Tuon that he hated Aes Sedai because of their meddling in politics on the kingdoms and not the fact they could channel and his relatives misunderstood and through the years their hated become linked to the fact they could channel. I read/hear somewhere that Robert Jordan wanted to make a sequel focusing on Mat and Tuon but unfortunately, there is very little information about the plot to try and make one of those unfinished tales like LoTR. You have my up vote, and I don't care if I get down voted into oblivion for support of your comment, because it's honestly what it looks like as the truth about this thread. You give just as much proof as they do as to how your statement is real and yet you are gonna get far more down votes than they will on it. ![]() I don't see why people downvoted your comment. He seemed the type that would accept love is love, toss the dice and see what turns up. Why is there always some one "pushing" and agenda trying to just be inclusive since there isn't much in the way of characters in existing classic fantasy that fit this? Honestly, I would say of the three men from the two rivers, Matt would be the most likely to be written this way for inclusivity. Like it's usually people who post "they are pushing an agenda with this" I don't get it. Everyone seems to think the show is trying to make everyone LGTBQ (sorry if I missed a letter, I think A gets on there too but I've been yelled at for adding things I wasn't sure on to that) Synology drive for linux8/18/2023 ![]() Monitors and logs detailed user actions and events, including file manipulations, permission modifications, and version rotations. ![]()
Picture Supply: Step 7: Construct the Roofįor the roof, you’ll want darkish oak stairs. Fill the entire remaining gaps with spruce logs. Now you’ll see some gaps are left behind. If you wish to add a balcony, put some spruce slabs on one facet of the home. ![]() form and lift them till they’re 9 blocks excessive in whole. To make a tower, begin inserting the identical easy sandstone blocks within the empty house. Fill in all of the gaps (aside from one half) by inserting sandstone two blocks large and 4 blocks excessive. Now we’re going to create our partitions with easy sandstone. Don’t overlook to attach the highest of the pillars with the identical spruce blocks. Now, add six strip spruce blocks on the highest to make a increase. Now place 4 spruce slabs in the course of all sides, so that they’re stage with the corners. On the highest of the construction, add upside-down spruce planks on the perimeters and one common block or spruce slab in between them. Now let’s start constructing the higher stage. Supply: Step 5: Add The Body to Construct Minecraft Medieval Home Repeat the identical factor on the highest of the partitions to make the bottom for the second stage. Now take some spruce planks and begin filling your floor flooring. After this, put three spruce trapdoors and eventually add a door. Then at a little bit free part, place three stones, three spruce fences. To make the primary entrance for the home, it’s a must to break some stones on one facet of the wall. Supply: Step 4: Construct a Doorway + Add the Flooring After doing this, your construction will look one thing like this: Repeat the identical course of with the nook blocks of the tower. Attempt to maintain the sample as random as potential to get a extra pure look.Īfter this, it’s time to exchange the primary nook blocks with polished andesite. You may also randomly texture the partitions with cobblestone and stone bricks. Use stones or blocksĪnd stack them on each other with a complete of 5 blocks excessive. With the structure offered, now let’s begin laying our basis. If you wish to add a basement, discover a land the place you’ll be able to dig simply! Step 3: Construct The Basis The general form of the home can be an L-shape, so discover a good flat space to construct your home. Step 2: Discover a Good Flat Place For Minecraft Medieval Home Right here is the record of all of the issues you should collect in case you construct wish to construct this home for survival: ![]() Right here is the design with which we are going to construct our home: So get able to design, assemble and construct.įirst, let’s speak concerning the primary supplies that you’ll want within the building of this construction. It is vitally simple to construct this home from assembled supplies, this home could be a nice survival place. Such a building would match completely within the middle of any medieval village or in a forest. It’s a easy constructing with some conventional architectural types. This medieval home was constructed by BlueNerd. Learn how to construct a straightforward medieval home On the higher flooring, you may as well create a library or further rest space.Īs well as, you’ll be able to construct an agricultural space and a secure for the remainder of your royal horses or donkeys. On the second flooring you’ll be able to create a bed room, a small brewing space and an out of doors terrace for sniping mobs (enemies). It has a big space for storing and a crafting desk. The kitchen is mostly constructed on the primary flooring or floor flooring. There’s additionally direct entry from the basement to the mining shaft (a small space for putting in a furnace). Listed below are among the frequent issues which might be normally included in a Minecraft Medieval Home:Ĭellar together with ovens and plenty of cabinets. However first, let me let you know some primary options of any Minecraft medieval home. On this weblog, I’ll let you know how you can construct a medieval Minecraft home in simply ten easy steps. So, in case you’re excited to construct your first medieval home, maintain studying. These houses gives you an aesthetic and genuine vintage environment. Whether or not you desire a sturdy Minecraft citadel constructed of stone or a easy oak nation village dwelling, you’ll be able to create a home of any form and dimension. At this time on this weblog, I’ll let you know about Minecraft Medieval Home. And in case you’re in search of some dwelling inspiration, you’ve got come to the correct web page. ![]() ![]() So, on this recreation, you’ll be able to construct any sort of home. Learn how to construct a small medieval Minecraft home?Īpart from Netflix these days, Minecraft’s uncommon homes are most likely the second hottest factor on the planet! Quickly after it was first launched, it grew to become actually common immediately, and now everybody (together with me) is hooked on this wonderful recreation. On sute shred company arkansas8/18/2023 ![]() To keep up with his continuing work, you can follow Alexander on Instagram, Read this Postīen speaking at the Capitol Visitors Center His latest project, a YouTube series titled Life with Cerebral Palsy | Q & A, is described on his film production company OUTCAST Productions’ YouTube channel as “Everything you wanted to know about living with a disability, especially cerebral palsy, but didn’t know how to ask.” Everyone must have moments where they have to look back and say thank you for all your help.”Īlexander’s disability advocacy continues the spirit of helping others along the way. ![]() ”Īlexander on location filming The Wounds We Cannot See.Īlexander shared, “A lot of the technology that I used was directly from Easterseals, so I started working with an Easterseals technology specialist when I was really little, and then that continued as I got older and grew up.”Īlexander has one thing he wants everyone to take away from his story: “I am only where I am today because of a lot of people who helped me along the way, and I think that is a very important lesson, not just for me or people with disabilities, but a lesson to people in general…No one gets where they are on their own. He recalled, “My parents were like, okay, we have a child with disabilities, what do we do? What kind of services are out there? And Easterseals was there for. It was Alexander’s parents who got him involved with Easterseals Massachusetts. When asked about his connection to Easterseals, Alexander laughed, “I really think Easterseals is in my blood!” That company saw Alexander’s work and immediately offered to finance his next project. “At the end of school, I got very lucky because I caught the attention of a production company,” he said. So, all through high school, I made films.” His other documentary, The Wounds We Cannot See, which shares one woman’s real battle with addiction, PTSD, and mental illness, is available for purchase on Amazon Prime Video.Īlexander described how filmmaking took the utmost priority in his life at an early age: “I didn’t really have a ton of friends in high school or a lot of room to socialize, so I was just like, ‘I don’t need people’ – I am just going to focus on what I am good at. Alexander has Cerebral Palsy and uses his own experiences and the true experiences of others to inspire his work. The documentary explores the topic of sexuality and intimacy from the eyes of disabled adults. Now an award-winning filmmaker and disability-rights activist, Alexander was recently featured in LA Weekly Magazine for his documentary, The Last Taboo. “I took the class and absolutely fell in love…I think, on a really basic level as humans, we are drawn to and we can’t help but listen to what’s happening on the screen,” Alexander explained. Years later, he admits his mom was right – taking that class inspired a new passion with the medium and launched his career. Notice to the public of rights under Title VIĪviso público de los derechos del Titulo VIĪs a teenager, Alexander Freeman was weary about listening to his mom’s suggestion of taking a film class in high school, but he eventually gave in. 4,100 kilowatt-hours of electricity - enough energy to power the average American home for 6 months!.According to ESPC, since November 2008, Super Shred has saved approximately 258 trees, which is equivalent to 15 tons of paper! Here's more information about the "green" benefits of shredding from the North American Factbook PPI: Why should you & your business shred? Click here to download a Super Shred brochure in pdf format.Īnother benefit of using "Super Shred" is - it's good for the planet! Shredded paper is recycled. For information on Super Shred & how it can benefit you, contact us online or call Horizon Industries at 81. Super Shred offers secure, convenient disposal of sensitive documents and other papers. "Super Shred" is now serving approximately two dozen local industries, businesses and individuals while also providing vocational opportunities for adults with disabilities. Super Shred at Horizon Industries Easterseals Posey County's "Super Shred" serves area businesses & provides vocational opportunities for adults with disabilities.Įasterseals Posey County, a division of the Easterseals Rehabilitation Center, started its paper shredding business in November 2008. Kap usa8/18/2023 ![]() Together, these data suggest that KAP plays a role in normal growth control and that deregulated KAP expression may contribute to the malignant phenotypes. ![]() In addition, blocking KAP overexpression resulted in a decreased population of S-phase cells during cell cycle progression and reduced Cdk2 kinase activity. We demonstrate further that selective inhibition of KAP overexpression by an antisense approach in the HeLa and LNCaP cancer cell lines decreased their transformed phenotype in vitro and their tumorigenicity in nude mice. We report that breast and prostate malignancies are associated with high levels of KAP expression. ![]() In an effort to search for candidate genes whose function or expression is altered causally in carcinogenesis, we identified the KAP gene as an overexpressed gene in human breast and prostate cancer using differential screening. Phosphatases have also been shown to play an important role in regulating a variety of signal transduction pathways that have a bearing on cancer (reviewed in references 5, 9, 29, 31, 36, and 39). However, the physiological substrate(s) for tyrosine dephosphorylation of KAP has not yet been identified.Īccumulating evidence suggests that deregulation of protein phosphorylation is a key event in neoplastic transformation. It has been reported that KAP may inactivate a specific protein kinase, probably Cdk2 or Cdc2, by removing phosphates from the cyclin complexes, and this may contribute to cell cycle control ( 2, 24, 42). However, the biological significance of the interactions remains to be elucidated. Further studies demonstrated that kinase-associated phosphatase (KAP) binds to Cdk2 and dephosphorylates Thr160 when the associated cyclin subunit is degraded or dissociated ( 2, 42). The identification of these negative regulators of Cdks has provided key insights into how the cell cycle can be controlled.Ī Cdk-interacting protein called KAP/Cdi1 was first identified as a novel G 1- and S-phase dual-specificity phosphatase that associates with Cdk2 and/or Cdc2 ( 22, 24). Among these, the mammalian G 1 Cdk inhibitors have been shown to be involved in diverse processes such as repair of DNA damage, differentiation, tumor suppression, and cellular senescence ( 12, 22, 24, 25, 37, 52). Proteins that interact with Cdks play distinct and specific roles in cell cycle regulation. The activity of these kinases depends on their association with a family of positive regulatory protein subunits known as cyclins during the cell cycle. These controls play important roles in preventing tumorigenesis ( 26, 28, 30, 31).Ĭell cycle progression in mammals requires multiple cyclin-dependent kinases (Cdks) ( 44). The transition from one stage of the cell cycle to another is regulated by the transcription of a number of cyclin genes, the degradation of cyclin proteins, and the modification of the cyclin-dependent kinase proteins by phosphorylation (reviewed in references 11, 29, and 30). Among normal cellular functions, regulatory control of the cell cycle plays an important role in normal cell proliferation, and genetic alterations that affect cell cycle control have been shown to be associated with tumor progression (reviewed in references 26, 28, 30, 32, 44, and 46). These alterations may involve the dysregulation of a variety of normal cellular functions, leading to the initiation and progression of a tumor. Human cancer development is a multistage process that results from the stepwise acquisition of genetic alterations. These findings suggest that therapeutic intervention might be aimed at repression of KAP gene overexpression in human breast and prostate cancer. Furthermore, lowering KAP expression led to inhibition of the transformed phenotype, with reduced anchorage-independent growth and tumorigenic potential in athymic nude mice. Blocking KAP expression by antisense KAP in a tetracycline-regulatable system results in a reduced population of S-phase cells and reduced Cdk2 kinase activity. In normal cells, KAP is primarily found in the perinuclear region, but in tumor cells, a significant portion of KAP is found in the cytoplasm. Here we report that breast and prostate malignancies are associated with high levels of KAP expression. We have identified the KAP gene as an overexpressed gene in breast and prostate cancer by using a phosphatase domain-specific differential-display PCR strategy. ![]() The kinase-associated phosphatase (KAP) is a human dual-specificity protein phosphatase that was identified as a Cdc2- or Cdk2-interacting protein by a yeast two-hybrid screening, yet the biological significance of these interactions remains elusive. Accumulating evidence suggests that phosphatases play an important role in regulating a variety of signal transduction pathways that have a bearing on cancer. AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |